General Information

  • ID:  hor006493
  • Uniprot ID:  Q9U8R2
  • Protein name:  Androgenic gland hormone B chain
  • Gene name:  NA
  • Organism:  Armadillidium vulgare (Pillbug) (Pill woodlouse)
  • Family:  NA
  • Source:  Animal
  • Expression:  Androgenic gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Armadillidium (genus), Armadillidiidae (family), Crinocheta , Oniscidea (suborder), Isopoda (order), Peracarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea , Mandibulata , Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0007283 spermatogenesis; GO:0007548 sex differentiation; GO:0030154 cell differentiation
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YQVRGMRSDVLCGDIRFTVQCICNELGYFPTERLDKPCPWPNRE
  • Length:  44(22-65)
  • Propeptide:  MKGLVILVSLMCLALYNRICAYQVRGMRSDVLCGDIRFTVQCICNELGYFPTERLDKPCPWPNREKRSAPEDELAFEDYEDQDYFHPRALSIPSEIEHDNEKESDAFSILSRGKREIAFYQECCNIRTEHKCNRTTVSLYCRTY
  • Signal peptide:  MKGLVILVSLMCLALYNRICA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Controls sex differentiation and the formation of male appendages, spermatogenesis, pigmentation, and male specific behavior.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  21-38
  • Structure ID:  AF-Q9U8R2-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006493_AF2.pdbhor006493_ESM.pdb

Physical Information

Mass: 597414 Formula: C227H351N65O66S5
Absent amino acids: AH Common amino acids: R
pI: 6.32 Basic residues: 6
Polar residues: 14 Hydrophobic residues: 11
Hydrophobicity: -55 Boman Index: -10462
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 64.09
Instability Index: 1787.95 Extinction Coefficient cystines: 8730
Absorbance 280nm: 203.02

Literature

  • PubMed ID:  10529379
  • Title:  Characterization and cDNA cloning of androgenic gland hormone of the terrestrial isopod Armadillidium vulgare.
  • PubMed ID:  10411634
  • Title:  The structure of a glycosylated protein hormone responsible for sex determination in the isopod, Armadillidium vulgare.